IC50 values of AS1069562 and duloxetine for 5-HT, NE, and DA reuptake activities
Values are the mean (95% confidence interval).
| IC50 of: | ||
|---|---|---|
| AS1069562 | Duloxetine | |
| μM | ||
| Human | ||
| 5-HT | 0.35 (0.27–0.47) | 0.013 (0.0059–0.028) |
| NE | 3.3 (1.4–7.9) | 0.016 (0.0072–0.036) |
| DA | >100 | 3.8 (2.3–6.1) |
| Rat | ||
| 5-HT | 0.38 (0.18–0.78) | 0.042 (0.022–0.080) |
| NE | 4.0 (3.5–4.6) | 0.013 (0.0039–0.043) |
| DA | >100 | 2.4 (1.5–4.2) |