TABLE 1
SIM plasma Cl and
V
d
P
values were calculated with the
t
test.
Pharmacokinetic Parameter
Control
MCD
P
Value
Mean ± S.E.M.
Cl (ml/min)
92 ± 8
132 ± 25
0.1702
V
d
(ml)
3199 ± 445
11,570 ± 2760
0.0171