ED50 values of antinociceptive effects and IGIT produced by oral administration of morphine, 7-hydroxymitragynine (7-OHMG), MGM-15, and MGM-16 in mice
ED50 represents the median effective dose (mg/kg) (95% confidence limits).
| Test | ED50 of: | |||
|---|---|---|---|---|
| Morphine | 7-OHMG | MGM-15 | MGM-16 | |
| mg/kg | ||||
| Tail-flick | 63.0 (37.2–106.8) | 4.43 (1.57–6.93) | 1.26 (0.84–1.88) | 0.263 (0.165–0.420) |
| IGIT | 11.7 (5.6–24.6) | 7.50 (3.95–14.2) | 2.20 (0.18–0.70) | 0.451 (0.230–0.882) |