[35S]GTPγS intrinsic efficacies and EC50 values of MGM-15, MGM-16, DAMGO, and [Met]-enkephalin in CHO-K1 cells expressing recombinant μ- and δ-opioid receptors
Each value represents the mean ± S.E.M. of three independent samples.
| Compound | μ-Opioid Receptor | δ-Opioid Receptor | ||
|---|---|---|---|---|
| EC50 | Emax | EC50 | Emax | |
| nM | nM | |||
| MGM-15 | 250 ± 61 | 72 ± 4.7 | 1492 ± 425 | 70 ± 4.9 |
| MGM-16 | 18 ± 0.055 | 94 ± 1.8 | 61 ± 3.2 | 105 ± 8.1 |
| DAMGO | 8.0 ± 0.69 | 100 | N.D. | N.D. |
| [Met]-enkephalin | N.D. | N.D. | 1.3 ± 0.26 | 100 |
N.D., not determined.