TABLE 3
Calculated parameters for nicotine-induced upregulation of [
3
H]epibatidine binding sites
h
α
4 Variant
Max Upregulation
Nicotine EC
50
fmol/mg
µM
Common
1262.34 ± 122.83
1.55 ± 0.66
α
4R336C
1154.67 ± 87.67
0.33 ± 0.15
α
4P451L
986.74 ± 218.29
0.77 ± 0.34
α
4R487Q
1197.21 ± 233.23
0.20 ± 0.06