Compound | BMS Agonist Pharmacophore | Diverse PXR Agonist Pharmacophore | Original PXR Agonist Pharmacophore | PXR Antagonist Pharmacophore | Lipophilicity |
---|---|---|---|---|---|
AlogP | |||||
Hyperforin | 4.71 | — | 2.92 | — | 9.06 |
Hyp1 | 1.93 | — | — | — | 3.33 |
Hyp5 | 2.32 | — | — | — | 4.25 |
Hyp7 | 4.03 | — | — | 2.51 | 5.81 |
Hyp8 | 2.92 | — | — | — | 5.33 |
Hyp9 | 4.13 | 6.87 | — | — | 4.65 |
Hyp2 | — | — | — | — | 2.22 |
Hyp3 | 5.35 | 5.88 | 2.84 | — | 13.78 |
Hyp4 | 3.39 | — | — | — | 3.56 |
Hyp6 | 0.58 | — | — | — | 2.53 |