Calculated acetylcholine concentration-response parameters after 24-hour nicotine
| hα4 Variant | HS EC50 | HS Max Response | LS EC50 | LS Max Response |
|---|---|---|---|---|
| µM | µM | |||
| Common | 3.36 ± 0.40 | 1.05 ± 0.02 | — | — |
| α4R336C | 18.3 ± 12.3 | 1.05 ± 0.54 | 222.0 ± 65.0 | 3.2 ± 0.50 |
| α4P451L | 6.26 ± 0.79 | 1.08 ± 0.02 | — | — |
| α4R487Q | 3.5 ± 1.0 | 0.80 ± 0.10 | 128.0 ± 35.0 | 1.0 ± 0.09 |