A comparison of pharmacokinetic parameters for nicotine and cotinine between Cyp2a5-null and Cyp2a(4/5)bgs-null mice
Values from Fig. 3 were used for calculating pharmacokinetic parameters. Data represent means ± S.D. (n = 4).
| Nicotine Dose | Analyte | Mouse Strain | AUC0-240 min | t1/2 | Tmax | Cmax | CL/F |
|---|---|---|---|---|---|---|---|
| ng·h/ml | min | ng/ml | ml/min | ||||
| 1 mg/kg | Nicotine | Cyp2a5-null | 116 ± 2.1 | 61.1 ± 1.5 | 5.0 ± 0.0 | 201 ± 35 | 3.38 ± 0.2 |
| Cyp2a(4/5)bgs-null | 220 ± 52* | 83.6 ± 13.2* | 5.0 ± 0.0 | 335 ± 54* | 1.5 ± 0.4* | ||
| Cotinine | Cyp2a5-null | 229 ± 27 | 148 ± 36 | 50.0 ± 17.3 | 72.6 ± 10.8 | N/A | |
| Cyp2a(4/5)bgs-null | 119 ± 3* | 120 ± 12 | 60.0 ± 0.0 | 39.9 ± 2.9* | N/A | ||
| 5 mg/kg | Nicotine | Cyp2a5-null | 297 ± 31 | 102 ± 36 | 5.0 ± 0.0 | 356 ± 66 | 6.78 ± 0.7 |
| Cyp2a(4/5)bgs-null | 499 ± 97* | 158 ± 28* | 5.0 ± 0.0 | 592 ± 149* | 3.16 ± 0.6* | ||
| Cotinine | Cyp2a5-null | 1870 ± 160 | 224 ± 48 | 75.0 ± 30.0 | 371 ± 25 | N/A | |
| Cyp2a(4/5)bgs-null | 1130 ± 30* | 204 ± 14 | 105 ± 30 | 225 ± 12* | N/A | ||
N/A, not applicable.
↵* P < 0.05 compared with corresponding Cyp2a5-null values.