Steady-state plasma and brain concentrations of sunitinib in wild-type, Mdr1a/b(−/−), Bcrp1(−/−), and Mdr1a/b(−/−)Bcrp1(−/−) mice after a constant intraperitoneal infusion of sunitinib at a rate of 30 µg/h for 48 hours (n = 4 each group)
Data presented as the mean ± S.D.
| Genotype | Plasma Css | Brain Css | Brain-to-Plasma Ratio |
|---|---|---|---|
| µg/ml | µg/g | ||
| FVB wild type | 0.19 ± 0.16 | 0.09 ± 0.06 | 0.51 ± 0.26 |
| Mdr1a/b(−/−) | 0.18 ± 0.15 | 0.39 ± 0.36 | 2.33 ± 0.56a |
| Bcrp1(−/−) | 0.19 ± 0.19 | 0.09 ± 0.04 | 0.73 ± 0.44 |
| Mdr1a/b(−/−)Bcrp1(−/−) | 0.26 ± 0.09 | 4.46 ± 1.66a | 17.44 ± 5.08a |
↵a P < 0.005 compared with wild type.