Summary of the effect of 2- and 14-day administration of carisbamate (CRS) and lamotrigine (LTG) on the firing and burst activity of dorsal raphe nucleus (DRN) 5-hydroxytryptoamine (5-HT), locus coeruleus (LC) norepinephrine (NE), and ventral tegmental area (VTA) dopamine (DA) neurons
| Drug | Area | TX | Firing Activity (Hz ± S.E.M.) | Bursting Vs. Nonbursting Neurons (%) | Burst Rate (Bursts/Min ± S.E.M.) | Mean # Spikes/Burst ± S.E.M. | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| Veh | TX | Veh | TX | Veh | TX | Veh | TX | |||
| CRS | DRN 5-HT | 2-day | 1.3 ± 0.07 | 0.9 ± 0.06*** | 37 | 23* | 15.8 ± 2.52 | 8.4 ± 1.74* | 2.1 ± 0.06 | 2.1 ± 0.05 |
| 14-day | 1.4 ± 0.08 | 1.1 ± 0.05** | 28 | 28 | 13.4 ± 2.92 | 12.1 ± 2.86 | 2.1 ± 0.04 | 2.1 ± 0.07 | ||
| LC NE | 2-day | 1.6 ± 0.09 | 1.5 ± 0.08 | 21 | 28 | 3.0 ± 0.62 | 2.6 ± 1.19 | 2.1 ± 0.05 | 2.0 ± 0.03 | |
| 14-day | 2.0 ± 0.09 | 1.3 ± 0.09*** | 40 | 21** | 2.3 ± 0.35 | 3.2 ± 0.69 | 2.1 ± 0.06 | 2.1 ± 0.05 | ||
| VTA DA | 2-day | 3.5 ± 0.18 | 3.6 ± 0.16 | 87 | 94 | 18.3 ± 2.29 | 18.5 ± 1.83 | 2.7 ± 0.13 | 2.9 ± 0.15 | |
| 14-day | 4.6 ± 0.17 | 3.4 ± 0.19*** | 99 | 96 | 30.9 ± 2.35 | 22.7 ± 2.41* | 3.3 ± 0.16 | 2.8 ± 0.12* | ||
| LTG | DRN 5-HT | 2-day | 1.1 ± 0.06 | 0.9 ± 0.05** | 34 | 29 | 11.7 ± 1.44 | 11.6 ± 1.91 | 2.1 ± 0.05 | 2.0 ± 0.04 |
| 14-day | 1.0 ± 0.06 | 0.8 ± 0.05** | 39 | 23 | 15.7 ± 3.19 | 11.5 ± 2.74 | 2.0 ± 0.03 | 2.1 ± 0.05 | ||
Veh, vehicle; TX, treatment.
↵* P < 0.05; **P < 0.01; ***P < 0.001.