nAChR agonist treatment does not affect parkinsonism
Monkeys were rated for parkinsonism once weekly throughout the study, starting 3–4 weeks after the last MPTP injection. The parkinsonian ratings shown were obtained in the same week as the data provided in Fig. 2 for varenicline and Fig. 4 for TC-8831, with similar results throughout the study. Values are the mean ± S.E.M. of the number of monkeys indicated in parentheses.
| Study | Parkinsonian Scores | ||
|---|---|---|---|
| Vehicle | Nicotine | nAChR Agonist | |
| Set A: varenicline | 4.7 ± 0.4 (6) | 3.6 ± 0.2 (5) | 4.0 ± 0.3 (12) |
| Set A: TC-8831 | 6.0 ± 1.3 (6) | 5.2 ± 0.4 (5) | 6.6 ± 0.8 (5) |
| Set B: TC-8831 | 5.3 ± 1.1 (6) | 5.0 ± 0.4 (5) | 5.8 ± 1.0 (5) |