TABLE 2

Sex-dependent differences in constitutive hepatic transporter gene expression in WT mice and mice genetically deficient in NKT, CD8⁺, B, and natural forkhead box P3⁺ regulatory T cells

Results represent the mean relative light units/10 μg total RNA ± S.E. (n = 3).

	Males		Females
Transporter	WT	TCR-α Tg Rag2 KO	WT	TCR-α Tg Rag2 KO
Oatp1a1	89.07 ± 26.73	100.32 ± 17.10	37.87 ± 22.75	4.41 ± 1.93
Oatp1a4	6.80 ± 1.30	5.09 ± 1.11	44.53 ± 5.91	27.09 ± 3.15
Oatp1b2	91.75 ± 8.18	93.07 ± 3.75	61.29 ± 14.74	50.60 ± 20.58
Ntcp	64.49 ± 12.90	97.89 ± 10.96	146.58 ± 21.35	163.08 ± 4.55
Oct1	128.78 ± 26.81	154.74 ± 14.71	182.76 ± 56.49	254.43 ± 49.54
Mrp3	6.31 ± 0.53	7.22 ± 1.98	9.30 ± 0.97	17.46 ± 3.07^**
Mrp2	28.95 ± 3.17	25.71 ± 4.91	24.38 ± 13.87	41.69 ± 5.16
Bsep	74.97 ± 12.99	60.70 ± 1.32	128.67 ± 56.47	102.47 ± 9.06

↵** P < 0.01, comparing sex-specific WT and TCR-α Tg Rag2 KO mice.