Compound | [35S]GTPγS Binding | cAMP Accumulation | |||
---|---|---|---|---|---|
D2S | D2L/Gαo | D2S | |||
pEC50 | Emax | pKB | pEC50 | Emax | |
% | % | ||||
Terguride | 8.96 ± 0.08 | 28 ± 1 | 9.87 ± 0.19 | 7.66 ± 0.20 | 57 ± 5 |
2-Chloroterguride | 8.68 ± 0.16 | 15 ± 1 | 9.76 ± 0.23 | ND | ND |
2-Bromoterguride | 8.87 ± 0.15 | 12 ± 1 | 9.86 ± 0.15 | 7.10 ± 0.16 | 28 ± 4 |
2-Iodoterguride | 8.56 ± 0.18 | 9 ± 1 | 9.62 ± 0.19 | ND | ND |
Aripiprazole | No agonism | – | 9.32 ± 0.23 | 7.06 ± 0.22 | 29 ± 3 |
ND, not determined.