Effects of LNP599 on cardiometabolic parameters in SHHF rats
| Effect | Control (n = 10) | LNP599 (n = 10) | P Value |
|---|---|---|---|
| DBP (mm Hg) | 166 ± 5 | 146 ± 9 | >0.05 |
| MBP (mm Hg) | 176 ± 6 | 156 ± 9 | <0.05 |
| SBP (mm Hg) | 203 ± 9 | 172 ± 10 | <0.05 |
| HR (bpm) | 361 ± 8 | 359 ± 6 | >0.05 |
| Total cholesterol (mM) | 3.8 ± 0.2 | 2.6 ± 0.1 | <0.0001 |
| Triglycerides (mM) | 4.6 ± 0.2 | 4.0 ± 0.4 | >0.05 |
| Free fatty acids (mM) | 0.94 ± 0.03 | 0.96 ± 0.06 | >0.05 |
| Plasma leptin (μg/l) | 14.4 ± 1.29 | 21.9 ± 2.20 | <0.01 |
| Plasma adiponectin (mg/l) | 5.54 ± 0.14 | 11.2 ± 0.81 | <0.0001 |
bpm, beats per minute; DBP, diastolic blood pressure; SBP, systolic blood pressure.