Toxicokinetics of oral GHB with and without ethanol coadministration
GHB and ethanol were administered concomitantly by oral gavage. t tests indicated no statistically significant differences in mean toxicokinetic parameters between groups. Data are presented as the mean ± S.D. (n = 4–5).
Dose Administered
CL/F
Cmax
Tmax
ml/kg per minute
μg/ml
h
GHB 1500 mg/kg PO
7.49 ± 1.1
492 ± 200
6.0 ± 2.5
GHB 1500 mg/kg PO + ethanol 2.5 g/kg
7.46± 1.6
489 ± 240
3.88 ± 4.4
CL/F, total clearance/bioavailability (oral clearance).