Toxicokinetics of intravenous GHB with and without ethanol coadministration
Ethanol was administered as a 1.0 or 2.0 g/kg i.v. bolus injection (followed by an infusion of 1.85 mg/min), resulting in target concentrations of 0.1–0.2 and 0.3–0.4% (w/v), respectively. GHB was administered 60 minutes after ethanol bolus administration. Results of one-way analysis of variance followed by Dunnett’s post hoc test indicated no statistically significant differences between mean toxicokinetic parameters in either ethanol-treated group compared with GHB alone. Data are presented as the mean ± S.D. (n = 5).
| Dose Administered | CL | CLR | CLm |
|---|---|---|---|
| ml/kg per minute | |||
| GHB 600 mg/kg i.v. | 5.84 ± 0.64 | 1.61 ± 0.48 | 4.22 ± 0.44 |
| GHB 600 mg/kg i.v. + ethanol 0.1–0.2% | 5.30 ± 0.58 | 1.76 ± 0.22 | 3.54 ± 0.46 |
| GHB 600 mg/kg i.v. + ethanol 0.3–0.4% | 5.91 ± 1.03 | 2.09 ± 0.98 | 3.82 ± 0.47 |