TABLE 2

Mean pharmacokinetics parameter estimates of CVX-343 following a single intravenous and subcutaneous administration (3 mg/kg) in mouse (n = 3), rat (n = 2), and monkey (n = 2)

Species	Intravenous					Subcutaneous
Species	t_1/)	AUC^{^a}	C_max	CL	Vss	t_1/2	T_max	C_max	AUC^{^a}	F
	hour	μg∙h/ml	μg/ml	ml/h/kg	ml/kg	hour	hour	μg/ml	μg∙h/ml	%
Mouse	28	435	38	6.9	222	37	13	4.4	298	69
Rat	60	1383	43	2.2	106	39	34	7	717	52
Monkey	65	1272	58	2.4	100	39	5.5	14	860	68

CL, clearance; Vss, volume of distribution at steady state.
↵^a Estimation based on intravenous or subcutaneous curve of a 5-day time period post dose in the mouse study, a 14-day time period post dose in the rat study, and a 21-day time period post dose in the monkey study.