Time course of antisialagogue effect of inhaled TD-4208, tiotropium, and glycopyrronium
Data represent the mean ± S.E.M. (n value).
| Compound | Dose (IH) | Inhibition of Pilocarpine | ||
|---|---|---|---|---|
| 1 h Postdose | 6 h Postdose | 24 h Postdose | ||
| μg/ml | % | |||
| TD-4208 | 3000 | 81 ± 2 (6) | 57 ± 4 (6) | 32 ± 8 (6) |
| Tiotropium | 100 | 28 ± 4 (6) | 64 ± 3 (5) | 45 ± 8 (6) |
| Glycopyrronium | 1000 | 90 ± 2 (5) | 78 ± 5 (6) | 51 ± 7 (6) |
IH, inhalation.