TABLE 2

Effects of SUN on electrophysiological recordings of dorsal root filaments in SNL rats

Firing activity mean ± S.E.M.; spontaneous activity, impulses/min, mechanically-evoked responses in impulses/10 trials.

von Frey Hair
TreatmentaSpontaneous1615
g pressure
Vehicleb1121 ± 10762 ± 8239 ± 23345 ± 21
SUNc351 ± 72**30 ± 7.2**140 ± 17**221 ± 21**

  • ↵a All treatments PO, 6–9 hours prior to recordings.

  • ↵b A total of 88 filaments was recorded from a total of 12 SNL rats (predosed with vehicle PO).

  • ↵c 122 filaments from 9 SNL rats (predosed with SUN, 10 mg/kg PO).

  • ↵** P < 0.001, compared with vehicle, unpaired Student’s t test.