TABLE 1

In vivo characteristics of untreated and treated sham and 5/6Nx rats 12 weeks after sham or 5/6Nx operation

Data are given as means ± S.E.M.

	Sham + Vehicle (n = 10)	Sham + PKI-166 (n = 12)	5/6Nx + Vehicle (n = 12)	5/6Nx + PKI-166 (n = 10)	5/6Nx + Lisinopril (n = 8)
Kidney weight (g)	1.59 ± 0.03	1.39 ± 0.05	2.32 ± 0.11^a^,^b	2.13 ± 0.13^a^,^b	2.08 ± 0.09^a^,^b
Kidney weight/body weight	0.35 ± 0.02	0.33 ± 0.01	0.49 ± 0.02^a^,^b	0.48 ± 0.04^a^,^b	0.43 ± 0.01^b
Creatinine clearance (ml/min.kg)	7.8 ± 0.7	7.3 ± 0.4	3.6 ± 0.4^a^,^b	2.9 ± 0.5^a^,^b	4.7 ± 0.6^a^,^b
Heart rate (beats/min)	355 ± 12	333 ± 12	355 ± 16	322 ± 15	358 ± 16
Left ventricular weight/body weight	0.21 ± 0.01	0.20 ± 0.003	0.25 ± 0.01^a^,^b^,^c	0.26 ± 0.01^a^,^b^,^c	0.20 ± 0.01
+dP/dt_max	9569 ± 505	8687 ± 462	10326 ± 404	8900 ± 482	8393 ± 685
-dP/dt_max	−7252 ± 354	−7322 ± 314	−8762 ± 398^a^,^c	−7674 ± 602	−6334 ± 437
LVSP (mm Hg)	119 ± 4	116 ± 4	151 ± 5^a^,^b^,^c	135 ± 7^c	108 ± 5
LVEDP (mm Hg)	4 ± 1	3 ± 1	13 ± 4^b^,^d	3 ± 1	4 ± 1

+dP/dt_max, maximal rate of increase in left ventricle pressure; −dP/dt_max, maximal rate of decrease in left ventricle pressure.
↵^a P < 0.05 versus sham + vehicle.
↵^b P < 0.05 versus sham + PKI-166.
↵^c P < 0.05 versus 5/6Nx + lisinopril.
↵^d P < 0.05 versus 5/6Nx + PKI-166.