Effects of morphine and WIN 55,212 alone and in combination on response rate (responses/second) in monkeys trained to discriminate 3.2 mg/kg morphine from saline
| Monkey | WIN 55,212 | Rimonabant | Morphine | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 0 | 0.32 | 0.56 | 1 | 1.78 | 3.2 | 5.6 | 10 | |||
| mg/kg | mg/kg | mg/kg | ||||||||
| CI | 0 | 0 | 2.6 (0)a | 2.7 (0.1) | 2.8 (0) | 3.2 (0.3) | 3.0b | 3.5b | ||
| 0.1 | 0 | 2.4 | 2.3 | 2.6 | 2.6 | 3.0 | 3.3 | |||
| 0.32 | 0 | 2.1 | 2.1 | 2.3 | 2.7 | 2.7 | 2.8 | |||
| 0.32 | 1.0 | 1.8 | 1.6 | 1.9 | 2.1 | 1.9 | 1.8 | |||
| HA | 0 | 0 | 3.1 (0.3) | 2.9 (0.1) | 2.8 (0.1) | |||||
| 0.1 | 0 | 3.1 | 2.4 | 2.6 | ||||||
| 0.32 | 0 | 3.2 | 2.3 | 2.4 | 2.1 | 2.1 | 1.9 | |||
| 0.32 | 1.0 | 3.1 | 3.0 | 2.7 | 2.7 | 2.5 | ||||
| AM | 0 | 0 | 3.6 (0.5) | 3.8 (0.4) | 3.9 (0.4) | 3.8 (0.4) | ||||
| 1.0 | 0 | 3.7 | 3.2 | 3.5 | ||||||
| 1.78 | 0 | 3.1 | 2.5 | 0.6 | 2.4 | 1.7 | 2.5 | |||
| 1.78 | 1.0 | 3.3 | 2.4 | 2.6 | 2.2 | |||||