Acetaminophen | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|
Unintentional | Intentional | Other Causes | ||||||||
Genotype | N | (%) | P Value | N | (%) | P Value | N | (%) | P Value | |
rs10929303 | C/C | 57 | (72) | *0.025 | 43 | (54) | 0.094 | 62 | (60) | 0.61 |
C/T+T/T | 22 | (28) | 36 | (46) | 41 | (40) | ||||
rs1042640 | C/C | 57 | (72) | *0.045 | 47 | (59) | 0.41 | 61 | (59) | 0.28 |
C/G+G/G | 22 | (28) | 32 | (41) | 42 | (41) | ||||
rs8330 | C/C | 56 | (71) | *0.027 | 42 | (54) | 0.13 | 60 | (58) | 0.50 |
C/G+G/G | 23 | (29) | 36 | (46) | 43 | (42) |
n = number of patients with each genotype group.
↵* P < 0.05 for χ2 test comparing differences in genotype numbers for the indicated acute liver failure group compared with the summed genotype numbers for the other two acute liver failure groups using the dominant effect genetic model (homozygous reference versus heterozygotes plus homozygous variant genotypes).