Analysis of concentration-response curves for the effects of the A1R agonist, CPA, on norepinephrine oxidation currents recorded from the surface of mesenteric arteries (MAs) and veins (MVs) from sham and DOCA-salt rats
pIC50 values and maximum inhibition were determined from nonlinear curve fits of concentration-response curves from individual preparations. Mean values were then compared using Student’s t test.
| Mesenteric arteries | N | pIC50 | % Max Inhibition |
|---|---|---|---|
| Sham | 9 | 7.6 ± 0.2 | 94 ± 2.0 |
| DOCA-salt | 9 | 6.4 ± 0.3* | 64 ± 4.2* |
| Sham | 5 | 8.5 ± 0.5 | 95 ± 3.6 |
| DOCA-salt | 6 | 8.6 ± 0.2 | 99 ± 1.4 |
A1R, A1 adenosine receptors; CPA, N6 cyclopentyl-adenosine; DOCA, deoxycorticosterone acetate; pIC50, negative log of the half maximal inhibitory drug concentration.
↵* Significantly different from sham values (P < 0.05).