Summary of the alcohol-related behaviors tested in WT and heterozygous GlyR D80A KI mice. Increases in behavior are indicated by ↑, decreases are represented with ↓, and = denotes no significant difference between the mutant mice and their WT littermate controls.
| Test | Behavior | Male | Female |
|---|---|---|---|
| Startle reflex | ↑ | ↑ | |
| Ethanol activation | ↓ | ↓ | |
| LORR | |||
| Ethanol | 3.8 g/kg | = | = |
| Pentobarbital | 50 mg/kg | ↑ | ↑ |
| Ketamine | 175 mg/kg | ↑ | ↑ |
| Flurazepam | 225 mg/kg | ↑ | ↑ |
| 2-Bottle choice | |||
| Ethanol 3%–15% | Ethanol intake | = | ↓ |
| Preference | = | ↓ | |
| Fluid intake | = | = | |
| Saccharin | Preference | = | = |
| Fluid intake | = | = | |
| Quinine | Preference | = | = |
| Fluid intake | = | ↓ | |
| Rotarod (recovery) | EtOH (2 g/kg) | = | = |
| Convulsions | Strychnine | = | = |
EtOH, ethanol; LORR, loss of righting reflex.