TABLE 1

Firing rates of VTA neurons: effects of inhibitors and quinpirole

FiguresChange by inhibitorsPre-quinpirole or DA baseline FR (Hz)Percentage change by DA or quinpirole at 5 min
Figure 1
 Control (no inhibitor)2.07 ± 0.17−72.78 ± 4.83
β-ARK1 inhibitor−2.71 ± 3.252.45 ± 0.27−64.47 ± 3.42
 Dynasore−2.51 ± 2.492.35 ± 0.24−62.99 ± 3.0
Figure 2
 Control (no inhibitor)2.55 ± 0.34−68.27 ± 4.94
 Neurotensin (10 nM)3.63 ± 0.38−65.5 ± 4.16
 Neurotensin (5 nM)3.15 ± 0.58−61.65 ± 6.2
β-ARK1 inhibitor−7.75 ± 3.531.8 ± 0.45−68.21 ± 6.85
 Gö69760.88 ± 3.01.38 ± 0.22−64.54 ± 6.24
 Dynasore−6.79 ± 3.91.75 ± 0.15−64.31 ± 6.35
Figure 3
 Serotonin2.53 ± 0.21−64.02 ± 5.38
β-ARK1 inhibitor−2.95 ± 1.942.23 ± 0.32−73.68 ± 5.93
 Gö6976−9.04 ± 3.631.41 ± 0.28−58.3 ± 2.75
 Dynasore−2.03 ± 2.632.59 ± 0.3−62.26 ± 6.57
  • β-ARK1 inhibitor, methyl 5-[2-(5-nitro-2-furyl)vinyl]-2-furoate; DA, dopamine; FR, firing rate; Gö6976 (5,6,7,13-tetrahydro-13-methyl-5-oxo-12H-indolo[2,3-a]pyrrolo[3,4c]carbozole-12-propanenitrile); VTA, ventral tegmental area.