TABLE 1

Pharmacokinetic parameters after oral and intravenous administration of MM-419447 to rats (10 mg/kg)

ParameterMM-419447
Tmax (h)0.33
Cmax (ng/ml)27.0
AUCi.v.(0–6 h) (ng-h/ml)a36,100
AUCPO.(0–6 h) (ng-h/ml)≤29.7a
Bioavailability (%)≤0.1a
  • a The ≤ symbol indicates that the reported value is an upper estimate of the area under curve (AUC) because the concentration of the lowest standard was used as the concentration of any sample with a concentration lower than the quantitation limit.