Effect of GS967 on rabbit myocyte resting membrane potential (RMP), peak rate of voltage change during the AP upstroke (Vmax), and action potential duration (APD)
Values are mean ± S.E.M., n = 4. (%) is percentage change from control (0 drug). Experiments were done at 36 ± 1°C.
| GS967 | RMP | Vmax | APD50 | APD90 |
|---|---|---|---|---|
| μM | mV (%) | V/s (%) | ms (%) | |
| 0 | −82.8 ± 0.7 | 309.0 ± 11.4 | 147.2 ± 13.6 | 184.3 ± 13.1 |
| 0.1 | −83.1 ± 0.5 (0.3) | 304.4 ± 12.5 (−1.6) | 143.1 ± 13.1 (−2.7) | 179.8 ± 13.1 (−2.5) |
| 1 | −82.7 ± 0.9 (−0.8) | 293.9 ± 11.2 (−4.9) | 138.1 ± 11.1 (−5.9) | 172.3 ± 13.1 (−6.6) |
| 3 | −83.2 ± 0.3 (0.5) | 272.0 ± 10.7 (−12.0) | 126.2 ± 10.5 (−14.1) | 162.8 ± 12.5 (−11.8) |