Potency of DOR-selective agonists deltorphin II, SNC80, ARM1000390, and ADL5859 in inducing calcium release
Data are from HEK-293 cells expressing DOR333-Gqi4 together with wild-type (WT) δ-opioid receptor (DOR) or μ-opioid receptor (MOR), or MOR354-Gqi4 together with WT DOR or MOR.
| Ligand | pEC50 (Mean ± S.E.M.) in Cells Expressing: | |||
|---|---|---|---|---|
| DOR333-Gqi4 + DOR | MOR354-Gqi4 + DOR | DOR333-Gqi4 + MOR | MOR354-Gqi4 + MOR | |
| Deltorphin II | 7.8 ± 0.1 | 7.3 ± 0.3 | 7.9 ± 0.1 | <5 |
| SNC80 | 7.7 ± 0.2 | 7.2 ± 0.2 | 7.0 ± 0.3 | <5 |
| ARM1000390 | 6.9 ± 0.2 | 6.5 ± 0.1 | 6.4 ± 0.1 | <5 |
| ADL5859 | 6.7 ± 0.1 | 5.9 ± 0.3 | 5.8 ± 0.2* | <5 |
↵* P < 0.05 vs. DOR333-Gqi4 + WT DOR.