Summary of the relative binding affinities of linaclotide and MM-419447
| Binding Assay | Ki ± S.E. | |
|---|---|---|
| Linaclotide | MM-419447 | |
| nM | ||
| T84 cells, pH 5.0 | 1.7 ± 0.8 | 0.9 ± 0.5 |
| T84 cells, pH 7.0 | 3.1 ± 1.4 | 1.8 ± 1.0 |
| T84 cells, pH 8.0 | 1.5 ± 1.8 | 1.6 ± 1.2 |
| Rat intestinal BBM, pH 7.0 | 2.6 ± 2.9 | 4.9 ± 2.8 |
BBM, brush-border membranes.