TABLE 3

ACh, nicotine and (±)-coniine concentration-effect curve EC50 and percentage maximum response values in the presence and absence of CTx GI and EI

Treatment, (n)EC50 ValueEC50 95% Confidence IntervalPercentage Maximum Response, Mean ± S.E.M.
μM
ACh control, (3)0.30.1–0.596 ± 2
 CTx EI, 1.0 μM, (3)1.40.6–2.8121 ± 7
 CTx GI, 1.0 μM, (3)0.30.09–1.1107 ± 7
Nicotine control (5)17.69.4–33.0116 ± 9
 CTx EI, 1.0 μM, (5)39.57.8–198114 ± 17
 CTx GI, 1.0 μM, (3)35.64.6–27336 ± 13*
(±)-Coniine control (6)12828–60039 ± 11
 CTx EI, 1.0 μM, (6)1835–9616 ± 3*
 CTx GI, 1.0 μM, (3)N.C.aN.C.a7 ± 2*

  • ↵* P < 0.05, two-way ANOVA, Bonferroni’s multiple comparisons test vs. control.

  • ↵a Not calculated due to poor fit.