Biochemical parameters in CETPtg/LDLR(−/−) mice treated with FXR agonists
Ten-week-old mice were fed a Western diet or a Western diet containing FXR compounds for 12 weeks. Blood was withdrawn after a 4 h-fasting. Data are expressed as mean ± S.E.M.
| Triglyceride | Cholesterol | Glucose | AST | |
|---|---|---|---|---|
| mmol/l | U/l | |||
| Control | 1.84 ± 0.21 | 22.63 ± 0.76 | 9.52 ± 0.86 | 19.9 ± 3.57 |
| PX20606, 5 mg/kg | 0.78 ± 0.13** | 11.84 ± 0.72** | 8.81 ± 1.93 | 18.8 ± 3.24 |
| PX20606, 25 mg/kg | 0.59 ± 0.07** | 8.81 ± 0.26** | 9.80 ± 0.78 | 17.9 ± 2.97 |
| 6-ECDCA, 10 mg/kg | 0.95 ± 0.06** | 17.49 ± 0.99** | 9.62 ± 1.06 | 17.3 ± 2.05 |
AST, aspartate aminotransferase.
↵** , statistical significance (p < 0.05).