TABLE 3

Recovery of linaclotide and MM-419447 from human feces after oral administration of linaclotide

Subject	% Active Peptide^{^a}
Subject	Dose 290 μg	Dose 2897 μg
Fasted
002	5.97	0^{^b}
004	0.39	0.28
005	2.53	2.94
008	NS	0^{^b}
011	NS	0^{^b}
012	0.49	5.73
015	0.37	2.78
018	6.72	11.76
019	17.75	6.57
Median	2.53	2.78
Mean	4.89	3.34
SD	6.3	4.0
Fed
001	NS	2.21
003	2.11	3.72
006	0^{^b}	0^{^b}
007	0.75	1.06^{^c}
009	8.18	5.20
010	2.51	2.57^{^d}
016	9.37	20.84^{^e}
017	0^{^b}	0^{^b}
020	1.97	0^{^b}
Median	2.04	2.21
Mean	3.11	3.96
SD	3.6	6.6

Values are shown as percentage of oral dose. NS, no sample available.
↵^a Percentage of active peptide present as MM-419447, unless noted.
↵^b Below detection limits.
↵^c 0.88% MM-419447, 0.18% linaclotide.
↵^d 2.22% MM-419447, 0.35% linaclotide.
↵^e 19.97% MM-419447, 0.87% linaclotide.