Compound | Abcg2(+/+) | Abcg2(−/−) | ||||||
---|---|---|---|---|---|---|---|---|
AUC0-inf | Cmax | Tmax | F | AUC0-inf | Cmax | Tmax | F | |
μg · h/l | ng/ml | h | % | μg · h/l | ng/ml | h | % | |
Nitrofurantoin | 4510 ± 1480 | 2550 ± 758 | 0.5 (0.5–1) | 82 ± 27 | 6930 ± 3380 | 2480 ± 734 | 1 (0.5–2) | 94 ± 46 |
Sulfasalazine | 175 ± 61.7 | 87.6 ± 12.5 | 0.25 | 1.1 ± 0.4 | 5800 ± 2340** | 1800 ± 327** | 1 (1–2) | 18.9 ± 7.6** |
Compound Aa | 40.8 ± 13.1 | 7.6 ± 4.2 | 1 (0.25–2) | 1.1 ± 0.4 | 399 ± 18.2* | 36.7 ± 3.5* | 1 (1–8) | 4.4 ± 2.0* |