TABLE 2

Antitumor efficacy of STA-9584 in vivo in a panel of xenograft models

Mice bearing established xenografts were intravenously dosed with STA-9584 at 4.5 mg/kg once weekly in all cases.

Cell LineSpeciesTumor Phenotype%T/C
EMT6MouseBreast carcinoma11
DaudiHumanB-cell lymphoma39
M14HumanMelanoma7
RERF-LC-AIHumanNSCLC5
PC-3HumanProstate carcinoma−40*
MDA-MB-231HumanBreast carcinoma−60*

  • ↵* , tumor regression.