TABLE 4 M3 kinetic selectivity ratios for tiotropium and NVA237 at M1–5 receptors based on a concentration 30-fold more than their Ki at the M3 receptor under physiological conditions of sodium ion concentration and temperature. Ratios were calculated based on the simulations shown in Fig. 4, A and B
The M3 kinetic selectivity ratio defines muscarinic receptor subtype selectivity as a ratio of area under the curve measures at M3 receptors over area under the curve measures for the individual subtypes.