Common Name | Gene Symbol | Liver | Brain | Kidney | Duodenum | Jejunum | Ileum |
---|---|---|---|---|---|---|---|
Mdr1a | Abcb1a | 1.00 ± 0.07 | 0.80 | 0.79 ± 0.29 | 1.35 ± 0.56 | 0.97 ± 0.05 | 0.57 ± 0.06 |
Mdr1b | Abcb1b | 0.32 ± 0.07* | 0.58 | 1.07 ± 0.22 | 0.79 ± 0.08 | 1.57 ± 0.18 | N.D. |
Mdr3 | Abcb4 | 0.81 ± 0.25 | N.D. | N.D. | N.D. | N.D. | N.D. |
Bsep | Abcb11 | 0.62 ± 0.26 | N.D. | 0.84 ± 0.42 | 0.73 ± 0.18 | 1.21 ± 0.11 | 0.44 ± 0.04* |
Mrp1 | Abc1 | N.D. | 0.54 | 0.75 ± 0.31 | 1.62 ± 0.16 | 1.73 ± 0.26 | 1.41 ± 0.08 |
Mrp2 | Abcc2 | 0.63 ± 0.21 | N.D. | 0.90 ± 0.37 | 0.96 ± 0.10 | 1.21 ± 0.17 | 0.32 ± 0.06* |
Mrp3 | Abcc3 | 0.39 ± 0.17* | 4.45 | 1.18 ± 0.36 | 1.92 ± 0.01 | 1.03 ± 0.18 | 1.73 ± 0.25 |
Mrp4 | Abcc4 | 1.02 ± 0.17 | 0.80 | 0.95 ± 0.38 | 1.70 ± 0.28 | 1.03 ± 0.09 | 0.95 ± 0.05 |
Mrp5 | Abcc5 | N.D. | 0.76 | 0.88 ± 0.58 | 1.77 ± 0.63 | 0.97 ± 0.12 | 1.15 ± 0.08 |
Mrp6 | Abcc6 | 0.56 ± 0.17 | 0.79 | 0.80 ± 0.48 | 2.17 ± 0.71* | 2.37 ± 0.37* | 1.14 ± 0.12 |
Bcrp | Abcg2 | 0.01 ± 0.01* | 0.00 | 0.00 ± 0.01* | 0.00 ± 0.00* | 0.00 ± 0.00* | 0.00 ± 0.00* |
N.A. | Abcg5 | 0.46 ± 0.20* | N.D. | N.D. | N.D. | N.D. | N.D. |
N.A. | Abcg8 | 0.90 ± 0.29 | N.D. | N.D. | N.D. | N.D. | N.D. |
Oatp1a1 | Slco1a1 | 0.72 ± 0.26 | N.D. | 1.15 ± 0.54 | N.D. | N.D. | N.D. |
Oatp1a4 | Slco1a4 | 0.87 ± 0.25 | 0.15 | 1.55 ± 0.41 | N.D. | N.D. | N.D. |
Oatp1a5 | Slco1a5 | N.D. | 1.30 | N.D. | N.D. | N.D. | N.D. |
Oatp1a6 | Slco1a6 | N.D. | N.D. | 1.20 ± 0.57 | N.D. | N.D. | N.D. |
Oatp1b3 | Slco1b3 | 1.06 ± 0.17 | N.D. | N.D. | N.D. | N.D. | N.D. |
Oatp2b1 | Slco2b1 | 0.50 ± 0.13 | 1.50 | 0.95 ± 0.30 | 2.13 ± 0.20* | 1.63 ± 0.07 | 0.92 ± 0.07 |
Oatp1c1 | Slco1c1 | N.D. | 1.10 | N.D. | N.D. | N.D. | N.D. |
OATP4c1 | Slco4c1 | N.D. | 0.62 | 1.32 ± 0.33 | N.D. | N.D. | N.D. |
Ntcp | Slc10a1 | 0.73 ± 0.17 | N.D. | N.D. | N.D. | N.D. | N.D. |
Asbt | Slc10a2 | N.D. | N.D. | 0.43 ± 0.21 | 2.11 ± 1.19* | N.D. | 4.2 ± 0.36* |
Pept1 | Slc15a1 | N.D. | N.D. | 1.05 ± 0.35 | 0.90 ± 0.22 | 1.02 ± 0.07 | 0.64 ± 0.04 |
Pept2 | Slc15a2 | N.D. | 0.80 | 0.80 ± 0.21 | 0.86 ± 0.33 | 0.31 ± 0.15* | 0.54 ± 0.09 |
Oat-k | Slc21a4 | N.D. | N.D. | 0.70 ± 0.15 | N.D. | N.D. | N.D. |
Oct1 | Slc22a1 | 1.12 ± 0.25 | N.D. | 0.79 ± 0.21 | 1.64 ± 0.33 | 1.05 ± 0.13 | 0.67 ± 0.06 |
Oct2 | Slc22a2 | N.D. | 1.35 | 1.24 ± 0.26 | N.D. | N.D. | N.D. |
OctN1 | Slc22a4 | N.D. | 0.52 | 0.53 ± 0.21 | 0.89 ± 0.14 | 2.83 ± 0.33* | 1.03 ± 0.13 |
OctN2 | Slc22a5 | N.D. | 2.38 | 0.84 ± 0.30 | 1.51 ± 0.24 | 1.27 ± 0.13 | 0.92 ± 0.07 |
Oat1 | Slc22a6 | N.D. | 0.67 | 0.63 ± 0.22 | N.D. | N.D. | N.D. |
Oat2 | Slc22a7 | 0.68 ± 0.20 | N.D. | 1.05 ± 0.39 | 0.70 ± 0.03 | N.D. | N.D. |
Oat3 | Slc22a8 | 1.43 ± 0.32 | 0.68 | 0.91 ± 0.40 | N.D. | N.D. | N.D. |
Oat8 | Slc22a9 | N.D. | N.D. | 1.16 ± 0.24 | N.D. | N.D. | N.D. |
Urat1 | Slc22a12 | N.D. | 1.13 | 0.88 ± 0.45 | N.D. | N.D. | N.D. |
Mate1 | Slc47a1 | N.D. | 1.12 | 0.91 ± 0.44 | N.D. | N.D. | N.D. |
N.A. | Cyp1a2 | 0.95 ± 0.22 | N.D. | N.D. | N.D. | N.D. | N.D. |
N.A. | Cyp2b2 | 0.41 ± 0.18* | N.D. | N.D. | N.D. | N.D. | N.D. |
N.A. | Cyp2c11 | 0.72 ± 0.25 | N.D. | N.D. | N.D. | N.D. | N.D. |
N.A. | Cyp2c23 | N.D. | N.D. | 0.87 ± 0.18 | N.D. | N.D. | N.D. |
N.A. | Cyp2d4 | 0.84 ± 0.31 | 0.77 | 1.31 ± 0.42 | 1.58 ± 0.50 | 1.37 ± 0.09 | 0.67 ± 0.06 |
N.A. | Cyp3a2 | 0.65 ± 0.30 | N.D. | N.D. | N.D. | N.D. | N.D. |
N.A. | Cyp3a9 | N.D. | 0.89 | N.D. | 0.97 ± 0.19 | 1.34 ± 0.15 | 0.54 ± 0.11 |
N.A. | Cyp3a18 | N.D. | N.D. | N.D. | 0.69 ± 0.19 | 1.12 ± 0.10 | 0.27 ± 0.05* |
N.A. | Cyp3a23/3a1 | 0.55 ± 0.15 | N.D. | N.D. | N.D. | N.D. | N.D. |
N.A. | Cyp4a1 | 0.57 ± 0.18 | N.D. | N.D. | N.D. | N.D. | N.D. |
N.A. | Ugt1a1 | 0.69 ± 0.20 | N.D. | 1.82 ± 0.43 | 1.74 ± 0.19 | 1.10 ± 0.04 | 0.70 ± 0.04 |
N.A. | Ugt1a6 | 0.92 ± 0.33 | 1.41 | 1.52 ± 0.42 | 1.04 ± 0.23 | 1.35 ± 0.07 | 0.75 ± 0.05 |
N.A. | Ugt1a7c | N.D. | 0.91 | 1.04 ± 0.44 | 1.50 ± 0.00 | 1.16 ± 0.11 | 0.58 ± 0.06 |
N.A. | Ugt2b1 | 0.56 ± 0.21 | N.D. | N.D. | N.D. | N.D. | N.D. |
N.A. | Ugt2b5 | 0.53 ± 0.24 | N.D. | N.D. | N.D. | N.D. | N.D. |
N.A. | Ugt2b7 | N.D. | N.D. | 1.74 ± 0.49 | 1.21 ± 0.48 | N.D. | N.D. |
N.A. | Ugt2b36 | 0.66 ± 0.24 | N.D. | 1.75 ± 0.55 | 0.59 ± 0.15 | 0.83 ± 0.17 | N.D. |
N.A., not available; N.D., not determined.
↵* Adjusted p < 0.05, fold change ≥2.