ISIS 388626 concentrations in tissues measured approximately 2 Days after the last dose (day 93) after 13 weeks of repeated dose administration and 13 weeks of recovery (day 182) in mice and monkeys
Values are presented as mean ± S.D. (n = 6 on day 93 and n = 4 on day 182).
| Dose | Day | ISIS 388626 Concentration (μg/g) in Tissue | |||
|---|---|---|---|---|---|
| Mouse | Monkey | ||||
| Kidney | Liver | Kidney | Liver | ||
| 1 mg/kg | 93 | 21.5 ± 10.9 | 0.37 ± 0.057 | 152 ± 73 | 2.19 ± 0.54 |
| 3 mg/kg | 93 | 32.2 ± 12.8 | 0.82 ± 0.156 | 236 ± 91 | 10.3 ± 3.3 |
| 182 | BLQ | BLQ | N.D. | N.D. | |
| 10 mg/kg | 93 | 43.6 ± 13.2 | 2.56 ± 0.58 | 414 ± 134 | 62 ± 20.7 |
| 182 | N.D. | N.D. | 2.69 ± 1.33 | 0.333 ± 0.391 | |
| 30 mg/kg | 93 | 58.6 ± 24.3 | 5.97 ± 1.81 | 658 ± 243 | 162 ± 58 |
| 182 | BLQ | BLQ | 4.18 ± 2.28 | 7.81 ± 6.04 | |
BLQ indicates mean concentrations that were below the lower limit of quantitation, which was 0.2 μg/g. N.D., not determined.