Dose | Day | ISIS 388626 Concentration (μg/g) in Tissue | |||
---|---|---|---|---|---|
Mouse | Monkey | ||||
Kidney | Liver | Kidney | Liver | ||
1 mg/kg | 93 | 21.5 ± 10.9 | 0.37 ± 0.057 | 152 ± 73 | 2.19 ± 0.54 |
3 mg/kg | 93 | 32.2 ± 12.8 | 0.82 ± 0.156 | 236 ± 91 | 10.3 ± 3.3 |
182 | BLQ | BLQ | N.D. | N.D. | |
10 mg/kg | 93 | 43.6 ± 13.2 | 2.56 ± 0.58 | 414 ± 134 | 62 ± 20.7 |
182 | N.D. | N.D. | 2.69 ± 1.33 | 0.333 ± 0.391 | |
30 mg/kg | 93 | 58.6 ± 24.3 | 5.97 ± 1.81 | 658 ± 243 | 162 ± 58 |
182 | BLQ | BLQ | 4.18 ± 2.28 | 7.81 ± 6.04 |
BLQ indicates mean concentrations that were below the lower limit of quantitation, which was 0.2 μg/g. N.D., not determined.