TABLE 1

Effect of H2-RAs on gastric lesions induced by IND in rats

IND (10 mg/kg p.o.) was administered after a 16-h fast, and gastric lesions were measured 24 h after IND administration. H2-RAs were given orally twice, 30 min before and 6 h after IND. Data represent mean ± S.E.M. (n = 7 rats).

DrugDoseLesion IndexLesion Index
mg/kg, p.o.mm% of VEH
Expt 1
    VEH25.6 ± 5.3100.0 ± 20.7
    CIM30 × 212.1 ± 1.3*47.4 ± 5.2
    CIM100 × 24.3 ± 1.7**16.8 ± 6.6
    CIM300 × 21.9 ± 1.2**7.4 ± 4.7
Expt 2
    VEH20.3 ± 3.0100.0 ± 14.8
    RAN3 × 219.1 ± 1.593.9 ± 7.4
    RAN10 × 210.6 ± 2.2*52.0 ± 11.1
    RAN30 × 22.8 ± 0.9**13.8 ± 4.4
    FAM1 × 213.6 ± 2.547.4 ± 5.2
    FAM3 × 29.0 ± 1.8*16.8 ± 6.6
    FAM10 × 22.0 ± 10.3**7.4 ± 4.7

  • ↵* , p < 0.05;

  • ↵** , p < 0.01 vs. VEH (Dunnett's test).