Drug | Dose | Lesion Index | Lesion Index |
---|---|---|---|
mg/kg, p.o. | mm | % of VEH | |
Expt 1 | |||
VEH | 25.6 ± 5.3 | 100.0 ± 20.7 | |
CIM | 30 × 2 | 12.1 ± 1.3* | 47.4 ± 5.2 |
CIM | 100 × 2 | 4.3 ± 1.7** | 16.8 ± 6.6 |
CIM | 300 × 2 | 1.9 ± 1.2** | 7.4 ± 4.7 |
Expt 2 | |||
VEH | 20.3 ± 3.0 | 100.0 ± 14.8 | |
RAN | 3 × 2 | 19.1 ± 1.5 | 93.9 ± 7.4 |
RAN | 10 × 2 | 10.6 ± 2.2* | 52.0 ± 11.1 |
RAN | 30 × 2 | 2.8 ± 0.9** | 13.8 ± 4.4 |
FAM | 1 × 2 | 13.6 ± 2.5 | 47.4 ± 5.2 |
FAM | 3 × 2 | 9.0 ± 1.8* | 16.8 ± 6.6 |
FAM | 10 × 2 | 2.0 ± 10.3** | 7.4 ± 4.7 |