TABLE 1

Cells of C. neoformans strain JEC21 were grown in minimal medium, 30°C, containing the indicated benzofuran derivative (20 μM added in 10 μl DMSO) or just the carrier (DMSO, 10 μl)

The increases in cell number were measured over 6- to 10-h periods. The generation times are the means of three to four experiments and were determined by linear regression with reliability values of 0.9 or above. The S.E. are shown.

DerivativeGeneration TimeS.E.
min
DMSO1674.8
    2a1846.6
    2b2195.8
    2c18914.4
    2d20521.2
    2e1947.8
    3c18819.6
    3g1806.8
    3dNo growth
    4No growth