Experimentally determined ED50 values (Zmix) and predicted additive ED50 values (Zadd) of mixtures of NOP agonists administered in combination with buprenorphine in the primate antinociceptive assay
| Zmix (95% CL) | Zadd (95% CL) | |
|---|---|---|
| mg/kg | ||
| Ro 64-6198 + buprenorphine | ||
| 0.1:1, Ro 64-6198/buprenorphine | 0.018 (0.017–0.019)* | 0.038 (0.031–0.045) |
| 0.3:1, Ro 64-6198/buprenorphine | 0.006 (0.004–0.008)* | 0.030 (0.025–0.035) |
| 1:1, Ro 64-6198/buprenorphine | 0.003 (0.0027–0.0033)* | 0.022 (0.019–0.026) |
| SCH 221510 + buprenorphine | ||
| 0.03:1, SCH 221510/buprenorphine | 0.016 (0.015–0.018)* | 0.035 (0.029–0.043) |
| 0.1:1, SCH 221510/buprenorphine | 0.007 (0.006–0.008)* | 0.025 (0.021–0.030) |
| 0.3:1, SCH 221510/buprenorphine | 0.001 (0.0007–0.0019)* | 0.015 (0.012–0.018) |
↵* An experimental ED50 value (mg/kg) was significantly different from the predicted additive ED50 value (p < 0.05).