ED50 (95% CL) | ED30 (95% CL) | Mean Dose Ratio | Mean pKB (95% CL) | |||||
---|---|---|---|---|---|---|---|---|
Vehicle + Buprenorphine | J-113397 + Buprenorphine | Naltrexone + Buprenorphine | Vehicle + Buprenorphine | J-113397 + Buprenorphine | Naltrexone + Buprenorphine | |||
mg/kg | ||||||||
Antinociception | 0.020 (0.008–0.051) | 0.030 (0.014–0.066) | 0.34 (0.14–0.79)* | 17.7 | 8.2 (8.0–8.4) | |||
Itch/scratching | 0.015 (0.008–0.027) | 0.016 (0.006–0.042) | 0.31 (0.14–0.71)* | 27.2 | 8.3 (7.8–8.7) | |||
Respiratory depression, VE | 0.032 (0.012–0.083) | 0.045 (0.017–0.12) | 0.43 (0.17–1.11) | 22.2 | 8.1 (7.6–8.6) |
Both mean dose ratio and pKB value were determined for the dosing condition, naltrexone + buprenorphine (n = 6). See Figs. 4 to 6 for other details.
↵* An ED50 value was significantly different from the ED50 value determined in the dosing condition vehicle + buprenorphine (p < 0.05).