TABLE 3

Relative bioavailability by two methods (F_AUC and F_Xu)

Ninety percent confidence interval (90% CI) is of geometric means. Paired t test was performed to compare two methods of calculating relative bioavailability, and results were not significant, p > 0.05.

ID	Relative Bioavailability
ID	F_AUC	F_Xu
1	0.75	0.70
2	1.20	0.66
3	0.92	0.98
4	0.98	0.65
5	0.50	0.66
6	0.73	0.91
7	7.32	3.05
8	0.91	0.77
9	1.29	1.41
10	1.14	1.03
11	1.21	1.90
12	0.88	1.09
13	0.76	0.83
14	1.53	1.33
15	1.80	1.36
16	1.06	1.02
17	1.56	1.67
18	1.22	2.19
19	N.A.	5.01
20	1.02	1.20
21	2.11	1.87
22	0.53	0.54
23	1.43	1.13
24	0.82	1.10
25	0.83	0.57
Mean	1.35	1.35
SD	1.33	0.96
90% CI	0.93 −1.35	0.95 −1.38

N.A., not available because the plasma concentration of [D₁₀]PheT after smoking was below the limit of quantitation.