TABLE 3

Chronic nicotine treatment increases α4(nonα6)β2* nAChR expression but does not affect α6β2* nAChR density in nucleus accumbens shell

125I-Epibatidine binding assays in the presence of α-CtxMII and 125I-α-CtxMII were done to determine α4(nonα6)β2* and α6β2* nAChR expression, respectively, as described under Materials and Methods. Each value represents the mean ± S.E.M. of 10 animals per group.

nAChR SubtypeBinding% Vehicle-Treated
Vehicle-TreatedNicotine-Treated
fmol/mg
α4(nonα6)β2* nAChR2.82 ± 0.293.75 ± 0.32*132 ± 9.09*
α6β2* nAChR0.81 ± 0.100.90 ± 0.13111 ± 15.5
  • * Significance of difference from vehicle-treated using a t test: p < 0.05.