TABLE 1

K_i values for varenicline at α6β2* and α4β2* nAChRs in rat and monkey striatum

[¹²⁵I]α-CtxMII competition studies were done in rat and monkey striatum to measure α6β2* nAChRs, whereas [¹²⁵I]epibatidine binding in the presence of α-CtxMII was used to detect α4β2* nAChRs. Results show that varenicline potently interacts with both α6β2* and α4β2* nAChRs. Data with nicotine are provided for comparison. The values represent the mean ± S.E.M. of eight rats or three monkeys.