TABLE 3

Effect of A-1165442 and ABT-102 on pain behavior after acute dosing in a mouse model of bone cancer pain

Injection of tumor cells into the femur induced ongoing pain (vehicle group: 0 ± 8.4%) and changes in palpation-evoked pain (vehicle group: 0 ± 8.4%) and in spontaneous ambulation (limb use) (vehicle group: 0 ± 9.1%). Efficacies for A-1165442 are shown as values ± S.E.M. for at least eight determinations. Percentage effects were calculated as follows: (1− ((A-1165442 value − sham value)/(vehicle value − sham value))) × 100. Fifteen days after tumor cell inoculation A-1165442 had no significant effect on the three behavioral endpoints.