TABLE 1

Plasma cotinine levels in monkeys receiving long-term nicotine treatment in their drinking water

Animals were given nicotine in their drinking water containing Gatorade to mask the bitter taste of nicotine. Nicotine was administered starting at a low dose of 50 μg/ml and gradually increased to a final concentration of 650 μg/ml. Blood was collected to measure plasma cotinine levels. The plasma cotinine levels were similar to those in smokers. Values are mean ± S.E.M. of the indicated number of animals.