Potencies and efficacies for dopamine and NGD 94-1 at wild-type and mutant D4 receptors
Data for the potencies (EC50, nM) and relative efficacies of dopamine and NGD 94-1 are expressed as the mean ± S.D. of three separate experiments. Increased (↑) or decreased (↓) values relative to the wild-type D4 receptor are expressed as fold changes within parentheses.
| Receptor | NGD 94-1 | Dopamine | ||
|---|---|---|---|---|
| Potency | Relative Efficacy | Potency | Relative Efficacy | |
| nM | % | nM | % | |
| Wild-type D4 | 0.57 ± 0.11 (1) | 44 ± 14 (1) | 4.1 ± 1.9 (1) | 74 ± 14 (1) |
| D4-T7.39A | 0.30 ± 0.04 (1.9↓) | 51 ± 7.9 (1.2↑) | 22 ± 13.6 (5.4↑) | 55 ± 3.4 (1.3↓) |