Rat | Human | Rat | ||||
---|---|---|---|---|---|---|
Capsaicin, IC50 | Acid | Capsaicin, IC50 | Acid | ΔT | Concentration | |
nM | % inhibition | nM | % inhibition | °C | μg/ml | |
A-889425 | 117.5 ± 18.0 | 99.8 ± 0.0 | 95.4 ± 11.0 | 97.4 ± 1.3 | 0.8 | 1.8 ± 0.2 |
A-993610 | 30.7 ± 9.1 | 99.1 ± 0.3 | 21.4 ± 2.7 | 98.0 ± 0.8 | 1.0 | 0.2 ± 0.1 |
A-1098807 | 26.9 ± 3.5 | 99.9 ± 0.0 | 14.8 ± 2.1 | 98.1 ± 1.2 | 0.6 | 2.8 ± 0.8 |
A-1098808 | 18.0 ± 1.8 | 99.9 ± 0.0 | 15.7 ± 1.4 | 97.9 ± 1.3 | 0.6 | 3.8 ± 0.1 |
A-1153818 | 29.0 ± 4.2 | 99.9 ± 0.0 | 32.2 ± 8.2 | 98.6 ± 0.8 | 0.8 | 0.8 ± 0.2 |
A-1241407 | 206.6 ± 40.5 | 96.5 ± 1.9 | 112.9 ± 31.9 | 95.1 ± 0.9 | 0.9 | 4.3 ± 1.4 |
A-889425, 1-(3-methylpyridin-2-yl)-N-(4-(trifluoromethylsulfonyl)phenyl)-1,2,3,6-tetrahydropyridine-4-carboxamide; A-993610, (S)-1-(3-chloropyridin-2-yl)-3-methyl-N-(4-(trifluoromethyl)phenyl)-1,2,3,6-tetrahydropyridine-4-carboxamide; A-1098807, 1-((R)-6-fluoro-2,2-dimethylchroman-4-yl)-3-((S)-7-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)urea; A-1098808, 1-((R)-6-fluoro-2,2-dimethylchroman-4-yl)-3-((R)-7-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)urea; A-1153818, 1-((R)-2,2-diethyl-7-fluorochroman-4-yl)-3-((R)-7-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)urea.