Potency and selectivity of test drugs for COX isoforms in the air pouch model
| Drug | Inhibition vs. Control | |
|---|---|---|
| % | ||
| Indomethacin | COX-1a | COX-2b |
| 0.3 mg/kg | 64 | 59 |
| 1 mg/kg | 92 | 89 |
| 3 mg/kg | 98 | 96 |
| SC-560 | ||
| 1 mg/kg | 82 | 8 |
| 2.5 mg/kg | 95 | 11 |
| 5 mg/kg | 98 | 24 |
| DFU | ||
| 1.5 mg/kg | 2 | 55 |
| 5 mg/kg | 6 | 94 |
| 15 mg/kg | 11 | 99 |
| Celecoxib | ||
| 0.3 mg/kg | 3 | 58 |
| 1 mg/kg | 14 | 91 |
| 3 mg/kg | 17 | 99 |
| Valdecoxib | ||
| 0.3 mg/kg | 3 | 70 |
| 1 mg/kg | 8 | 95 |
| 3 mg/kg | 16 | 94 |